Description
Calcitriol-d6 is intended for us as an internal standard for the quantification of calcitriol by GC- or LC-MS. Calcitriol is synthesized from 7-dehydro cholesterol in humans
via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy vitamin D
3, the principal circulating form of vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone
via the direct stimulation of osteoblasts.
Chemical Properties
Off-White to Pale Yellow Solid
Uses
The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic
Uses
1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d
6?can be used as an analytical standard for the quantitative analysis of dihydroxyvitamin D3?concentration in human serum via LC-MS.
General Description
1α,25-Dihydroxyvitamin D3?[1,25(OH)
2D
3], also known as calcitriol, plays a role in calcium and phosphate metabolism in humans. It also regulates insulin secretion and induces cellular differentiation.
1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d
6?is a deuterated vitamin D3 wherein C-26 and C-27 carbon methyl protons are replaced by deuterium.
