Uses
NQ 301 possess antiplatelet effect, making it an antithrombotic agent. It significantly inhibited the collagen-?, thrombin-?, arachidonic acid-?, thapsigargin- and calcium ionophore A23187-?induced aggregation of washed human platelets.
Biochem/physiol Actions
NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.
