Originator
Modamate,Abbott,US,1960
Uses
L-Arginine L-Glutamate is used in the making of solution of arginine glutamate for the healing of radiation-induced skin ulcers in guinea pigs
Uses
Intravenous ammonia detoxicant in cases of liver failure.
Definition
ChEBI: Arginine glutamate is a glutamic acid derivative.
Manufacturing Process
This salt may be prepared by mixing L-arginine with L-glutamic acid in water
and crystallizing the resulting salt from the water by the addition of a polar
water miscible organic solvent to the water. For instance, when 17.2 g of Larginine
and 14.5 g of L-glutamic acid were dissolved in 155 g of water, a
clear homogeneous solution resulted which had a pH of 5.3. This solution was
filtered and the filtrate was evaporated at 50°C under reduced pressure to a
solution having a solids content of about 45%. Absolute methanol (220 g) was
added to the concentrated solution of the salt and this mixture cooled to 5°C
for one hour. The resulting solid salt was removed from the mixture by
filtration and washed with absolute methanol. After being dried preliminarily in
the air, the salt was further dried in a vacuum oven at 60°C for 3 hours. The
resulting salt, L-arginine-L-glutamate, weighed 30 g (94.6% of the
theoretically possible yield based on the amount of L-arginine and L-glutamic
acid employed) and melted at 193-194.5°C with decomposition.
brand name
Modumate (Abbott).
Therapeutic Function
Ammonia detoxicant (hepatic failure)
General Description
White powder.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
A dipeptide; hence an amide.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Arginine L-glutamate emits toxic fumes.
