Chemical Properties
white to light yellow crystalline powder
Uses
1-(Diphenylmethyl)piperazine [
N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene.
Uses
Cinnarizine (C465300) impurity.
Uses
1-Benzhydrylpiperazine is an intermediate used in drug synthesis
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 1098, 1955
DOI: 10.1021/ja01610a006
General Description
1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(
tert-butyl)-
o-benzoquinones.
Flammability and Explosibility
Not classified
