Chemical Properties
white powder
Uses
C12 Ceramide (d18:1/12:0) or
N-lauroyl-D-
erythro-sphingosine has been used:
- as a lipid standard in the optimization of the liquid chromatography-mass spectrometry (LC-MS) method conditions
- as an internal standard for lipid extraction in U87MG (human glioma cell line)
- as an internal standard for the quantification of ceramide using liquid chromatography-mass spectrometry (LC-MS) in rat tissues
Uses
Ceramide is one of the simplest sphingolipids, consisting of a sphingosine base N-linked to a fatty acid, and is a membrane mediator for cell-signaling events. N-Acyl chain length of membrane ceramides can influence bidimensional transitions, condensed domain morphology, and interfacial thickness.
Definition
ChEBI: N-dodecanoylsphingosine is a N-acylsphingosine in which the ceramide N-acyl group is specified as dodecanoyl (lauroyl). It is functionally related to a dodecanoic acid.
General Description
Ceramide is a sphingolipid with long acyl chain attached to a fatty. It is synthesized in the endoplasmic reticulum by ceramide synthase.
Biochem/physiol Actions
Ceramides?are signaling sphingolipids, which are implicated in regulating stress responses and inflammation. It also regulates cell growth arrest, differentiation and apoptosis.
