Synthesis
2-(3-Fluorophenyl)acetaldehyde was synthesized by oxidation reaction using 3-fluorophenethyl alcohol as starting material. The steps were as follows: 1. 3-Fluorophenyl ethanol was reacted with an oxidizing agent (e.g., PCC or Swern oxidizing reagent) in a suitable solvent at 0 °C to room temperature. 2. After completion of the reaction, the target product, 2-(3-fluorophenyl)acetaldehyde, was obtained by extraction and purification by column chromatography. This synthetic route is efficient and selective and is suitable for laboratory scale preparation.
References
[1] Patent: WO2008/36294, 2008, A2. Location in patent: Page/Page column 4; 6/8
[2] Patent: WO2008/42353, 2008, A1. Location in patent: Page/Page column 35; 41-42
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 779 - 797
[4] Patent: WO2012/97121, 2012, A2. Location in patent: Page/Page column 14
