Chemical Properties
Phenazopyridine is a red crystalline compound. Slightly soluble in water.
Originator
Phenazopyridine
,AroKor Holdings Inc.
Uses
An azo dye used in treatment of urinary tract infections. 3-(Phenylazo)-2,6-pyridinediamine is used as an analgesic (urinary tract).
Uses
An azo dye used in treatment of urinary tract infections. Used as an analgesic (urinary tract).
Definition
ChEBI: A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorder
) and potential carcinogenicity.
Manufacturing Process
Phenyldiazene chloride reacted with 2,6-diaminopyridine and in the result 2,6diamino-3-(phenylazo)pyridine was obtained.
In practice it is usually used as monohydrochloride.
brand name
Pyridium (Parke-Davis);Azo gantrisin;Azodine;Phenazo;Pyridiate;Pyronium;Sedural.
Therapeutic Function
Urinary analgesic, Antiseptic, Diagnostic aid
World Health Organization (WHO)
Phenazopyridine, an azo dye, was introduced in the 1950s as a
urinary antiseptic. It was withdrawn in Greece in 1984 on grounds that it has a
carcinogenic potential but it remains available in other countries, most frequently
as a constituent of combination products.
Safety Profile
Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental neoplastigenic data. Used as a local anesthetic. When heated to decomposition it emits toxic fumes of NOx.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
