POLY-L-ARGININE HYDROCHLORIDE

Uses

Poly-L-arginine hydrochloride has been used:

• to generate complex with stimulatory RNA isRNA9.2 as in neutrophils
• used in ribosomal RNA transfection into human monocytic THP-1 cells
• for coating alginate capsule beads

Uses

Poly-L-arginine hydrochloride has been used:

• as polyelectrolyte solution in the synthesis of biodegradable capsules
• as layer constituent, in the preparation of layer by layer (LbL) assembly of multilayer biodegradable shells
• in assay for the determination of binding activity of C-reactive protein for polycationic ligands

General Description

Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.

Biochem/physiol Actions

Poly-L-arginine (PLA) possesses anti-bacterial activity. It has a greater capacity to enhance membrane permeability. PLA at lower concentration enhances cell proliferation and at higher concentration acts as antiproliferative agent.