Uses
R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system.
Uses
R-(+)-DIOA has been used as a potassium/chloride K
+-Cl
- transport inhibitor to study its effects on:
- short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
- uptake of grepafloxacin by THP-1 monocytes
- the uptake of moxifloxacin by THP-1 monocytes
Biochem/physiol Actions
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.
