Synthesis
1. 2,4-Dichlorophenol, hydrazine hydrate, and propargyl chloride were used as the main raw materials, and propargyl oxacillin was synthesized by a six-step reaction including nitration, reduction, diazotization, acylation, cyclization, and etherification, with an overall yield of 35.5%.
2. 2,4-Dioxophenol was used as the starting material. After etherification, nitration, reduction to produce intermediate substituted aniline; then acylation, and finally with phosgene ring is obtained.
3. The hydrolysis of oxacillin is used to obtain oxacillinol, and then oxacillinol in the presence of polar solvent C2 ~ C5 fatty alcohols, inorganic alkali as the acid-binding agent, in the role of the catalyst, under 0.1 ~ 0.4MPa alkylation reaction to produce propargyl oxacillinol alcohol solution, and then filtration, washing, removal of some of the polar solvent C2 ~ C5 fat alcohols at negative pressure, crystallization and filtration, cooling, Drying to get propargyl oxazolone.
