Chemical Properties
light brown needle-like crystalline powder
Uses
2-?Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.
Uses
For the determination of copper, zinc and uranium with which it forms insoluble salts.
Definition
ChEBI: A quinolinemonocarboxylic acid having the carboxy group at the 2-position.
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 1840, 1946
DOI: 10.1021/ja01213a045
General Description
Quinaldic acid is also referred as quinoline-2-carboxylic acid. Microwave-assisted preparation of substituted anilides of quinaldic acid has been reported. It inhibits the oxidation of pyruvate, α-ketoglutarate, glutamate and citrate in rat liver mitochondria. Quinaldic acid is a metabolite of tryptophan degradation and inhibits the gluconeogenesis in perfused livers.
Purification Methods
Crystallise quinaldic acid from *C6H6 or AcOH. It is used for the estimation of many metals. The methyl ester has m 86-87o (from hexane) and pK25 1.76. [Chauduri et al. Frez Z Anal Chem 281 361 1976, Beilstein 22 H 71, 22 II 55, 22 III/IV 1149, 22/3 V 183.]
