Chemical Properties
white crystalline powder
Uses
N,N-Methylene-bis-acrylamide is an organic intermediate; cross-linking agent for preparation of polyacrylamides; in preparing poly-acrylamide gel for
e1ectrophoresis, chemical grouting and other purposes; in NAPP and Nyloprint UV-cured printing plates.
Uses
Organic intermediate, cross-linking agent.
Uses
N,N'-Methylenebisacrylamide is used in the preparation of polyacrylamide gels for electrophoretic separation of nucleic acids and proteins. It has also been used as a test compound for studying the biochemical isolation of insoluble Tau in transgenic mouse models of tauopathy by examining the two main isolation methods sarkosyl and formic acid extraction.
General Description
White crystalline powder with a neutral odor.
Air & Water Reactions
Very slightly water soluble.
Reactivity Profile
N,N'-Methylenebisacrylamide is incompatible with strong oxidizers, strong acids and strong bases.
Hazard
Toxic by ingestion.
Fire Hazard
Flash point data for N,N'-Methylenebisacrylamide are not available; however, N,N'-Methylenebisacrylamide is probably combustible.
Safety Profile
Poison by ingestion.
Experimental reproductive effects. Mutation
data reported. When heated to
decomposition it emits toxic fumes of NOx.
Purification Methods
Recrystallise the amide from MeOH (100g dissolved in 500mL boiling MeOH) and filter without suction in a warmed funnel. Allow to stand at room temperature and then at -15oC overnight. The crystals are collected with suction in a cooled funnel and washed with cold MeOH. The crystals are air-dried in a warm oven. [Beilstein 2 IV 1472.] VERY TOXIC (neurotoxic).
