Description
Prostaglandins have a short life
in vivo because NAD
+-
dependent 15-
hydroxy prostaglandin dehydrogenase (15-
PGDH) catalyzes their oxidation to 15-
keto metabolites with greatly reduced biological activity.
1 Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-
PGDH inhibitory activity.
2,3 CAY10638 is a TZD derivative that inhibits 15-
PGDH activity with an IC
50 value of 31 nM.
3
Definition
ChEBI: CAY10638 is an aromatic ether.
References
1. Hansen, H.S.
15-Hydroxyprostaglandin dehydrogenase. A review Prostaglandins 12(4),647-679(1976).
2. Owens, D.R.
Thiazolidinediones. An pharmacological overview Clin. Drug Investig. 22(8),485-505(2002).
3. Wu, Y., Tai, H.H., and Cho, H.
Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors Bioorg. Med. Chem. 18,1428-1433(2010).
