alpha-Azido-omega-hydroxy octa(ethylene glycol)

Description

Azide-PEG8-alcohol is a click chemistry reagent with an azide(N3) and a terminal hydroxyl group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl (OH) group enables further derivatization or replacement with other functional groups.

Uses

O-(2-Azidoethyl)heptaethylene glycol is used to synthesize oligo and poly(ethylene glycol) derivatives that are used as structural units of dendrimers, hydrogels, surface modifiers, self-assembling systems and molecular crosslinkers. This precursor is compatible for acetylene-azide click reactions.

Some of the reported applications include:

• Synthesis of strain-stiffening hydrogels through self-assembly of oligomers fibres derived from Azido-PEG (n=7).
• Synthesis of biodegradable tetra-PEG hydrogels for drug delivery system.
• Synthesis of heterobifunctional oligo(ethylene glycol) linkers for bioconjugation and targeted drug delivery.
• Preparation of synthetic amphiphiles for programmed pH-dependent dispersions of carbon nanotubes (CNTs).
• Selective glycoprotein detection through allosteric click-imprinting by using a self-assembled monolayer developed from the above oligomer.
• Preparation of bioactivated quantum dot micelles containing fluorescent nanocrystals.

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

IC 50

PEGs