Uses
(3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol is a follicular fluid meiosis-activating sterol (FF-MAS); a factor present in the pre-ovulatory follicle during the time of oocyte maturation. (3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol has been shown to protect young oocytes from precocious chromatid separation as well as protecting aged oocytes from predivision during maturation.
Definition
ChEBI: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol is a 3beta-sterol and a Delta(14) steroid. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It derives from a hydride of a 5alpha-cholestane.
Biological Activity
14-demethyl-14-dehydrolanosterol (FF-MAS) was first identified in follicular fluid of women and plays a key role in oocyte nuclear maturation. The levels of FF-MAS may be regulated by cytochrome P450 family 27 subfamily A member 1. Supplementation of FF-MAS to oocytes promotes meiotic maturation favoring preimplantation. However, FF-MAS has low solubility and is metabolized to cholesterol rapidly.