Description
Nocardamine is a ferrioxamine siderophore that has been found in
Streptomyces and has diverse biological activities. It chelates iron in a chrome azurol S assay (IC
50 = 9.9 μM). Nocardamine inhibits
M. smegmatis and
M. bovis biofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron. It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC
50s = 6, 18, 12, and 14 μM, respectively). Nocardamine also induces morphological changes in BM-N4 insect cells.
Uses
Nocardamine is a cyclic siderophore.
Definition
ChEBI: A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.
References
[1] VINCENT NORMANT. Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter[J]. ACS Chemical Biology, 2020, 15 10: 2741-2751. DOI:
10.1021/acschembio.0c00535[2] UEKI M, SUZUKI R, TAKAMATSU S, et al. Nocardamin Production by Streptomyces avermitilis[C]//285 1. 2009: 0. DOI:
10.3209/saj.saj230203[3] HONG-FA YAN. Ferroptosis: mechanisms and links with diseases.[J]. Signal Transduction and Targeted Therapy, 2021, 6 1: 49. DOI:
10.1038/s41392-020-00428-9[4] NATALIYA I. KALINOVSKAYA . Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity[J]. Microbiological research, 2011, 166 8: Pages 654-661. DOI:
10.1016/j.micres.2011.01.004[5] F. MAHMUD. Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809[J]. Molecules, 2022. DOI:
10.3390/molecules27072292
