Chemical Properties
Light Brown Residue
Uses
A sphingosine derivative. A sphingolipid compound found in the the umbilical cord artery of women with preeclampsia.
Uses
Glucosyl(β) Sphingosine (d18:1) or D-glucosyl-β1-1′-D-
erythro-sphingosine may be used:
- to screen lipids that rapidly and reversibly alter?transepithelial?electrical resistance (TER) or tight junction (TJ) permeability in epithelial tissue
- as a standard for the quantification of glucosyl sphingosine?in Gaucher patients using liquid chromatography electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS)
- as an internal standard for the quantification of lysoglucosylceramide in plasma for Gaucher disease using liquid chromatography with tandem mass spectrometry (LC-MS/MS)
Definition
ChEBI: Beta-D-glucosylsphingosine is d-Glucosylsphingosine in which the anomeric configuration of the glucosyl moiety is beta. It is a D-glucosylsphingosine and a beta-D-glucoside. It is a conjugate base of a beta-D-glucosylsphingosine(1+).
General Description
Glucosyl?sphingosine is a lyso derivative of glucosylceramide (GlcCer).
Biochem/physiol Actions
Glucosyl?sphingosine is a potential biomarker for Gaucher′s?disease.?It modulates?Ca2+?release?in the brain?microsomes.
