Uses
Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects[1][2][3].
References
[1] Maxime Cazorla, et al. Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice. PLoS One. 2010 Mar 19;5(3):e9777. DOI:
10.1371/journal.pone.0009777[2] Luis Constandil, et al. Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J Pain. 2012 Jun;13(6):579-89. DOI:
10.1016/j.jpain.2012.03.008[3] Michel M M Verheij, et al. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. J Neurosci. 2016 Aug 3;36(31):8149-59. DOI:
10.1523/JNEUROSCI.2711-14.2016[4] NATASHA M SOSANYA. Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain.[J]. BMC Neuroscience, 2019, 20 1: 17. DOI:
10.1186/s12868-019-0500-1
