Description
2,2’Dicarboxybiphenyl acid is also known as diphenic acid, being a useful pharmaceutical intermediate and used in the synthesis of dyes. Diphenic acid derivatives have attracted great attention due to its possession of useful therapeutic properties. Many diphenic acids derivatives have the potential of lowering the risk of chronic diseases such as cancer, cardiovascular diseases and other pathologies. It is applied in many herbs and components of food. Diphenic acids derivatives can usually be found in fruits like blackberry, raspberry and strawberry.
Sources
https://www.alfa.com/zh-cn/catalog/A15863/
https://www.tandfonline.com/doi/abs/10.1080/00397911.2017.1298805?journalCode=lsyc20
Chemical Properties
Off-white powder
Definition
ChEBI: Diphenic acid is a dicarboxylic acid. It is a conjugate acid of a diphenate(1-). It derives from a hydride of a biphenyl.
Synthesis Reference(s)
Journal of the American Chemical Society, 82, p. 2876, 1960
DOI: 10.1021/ja01496a051Organic Syntheses, Coll. Vol. 1, p. 222, 1941
Synthesis, p. 731, 1982
Purification Methods
Crystallise diphenic acid from water. Hot Ac2O provides the anhydride below. [Beilstein 9 H 922, 9 IV 3552.]
