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2-Bromoacetophenone

2-Bromoacetophenone Structure
2-Bromoacetophenone
  • CAS No.70-11-1
  • Chemical Name:2-Bromoacetophenone
  • CBNumber:CB6305185
  • Molecular Formula:C8H7BrO
  • Formula Weight:199.04
  • MOL File:70-11-1.mol
2-Bromoacetophenone Property
  • Melting point: :48-51 °C (lit.)
  • Boiling point: :135 °C/18 mmHg (lit.)
  • Density  :1.476
  • refractive index  :1.5700 (estimate)
  • Flash point: :>230 °F
  • storage temp.  :2-8°C
  • form  :Crystals or Powder
  • color  :White to dark green-brown
  • Water Solubility  :PRACTICALLY INSOLUBLE
  • Merck  :14,1402
  • BRN  :606474
  • Stability: :Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
  • InChIKey :LIGACIXOYTUXAW-UHFFFAOYSA-N
  • CAS DataBase Reference :70-11-1(CAS DataBase Reference)
  • FDA UNII :754Y0U325I
  • NIST Chemistry Reference :Ethanone, 2-bromo-1-phenyl-(70-11-1)
  • EPA Substance Registry System :Ethanone, 2-bromo-1-phenyl- (70-11-1)
Safety
  • Hazard Codes  :C
  • Risk Statements  :34-20/21/22
  • Safety Statements  :26-36/37/39-45
  • RIDADR  :UN 2645 6.1/PG 2
  • WGK Germany  :3
  • F  :8-19
  • Hazard Note  :Corrosive
  • TSCA  :Yes
  • HazardClass  :6.1
  • PackingGroup  :II
  • HS Code  :29143990
  • NFPA 704:
    1
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H310+H330-H318-H331-H314
  • Precautionary statements P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P310-P260-P262-P264-P270-P271-P284-P301+P330+P331+P310-P303+P361+P353+P310+P363-P305+P351+P338+P310-P403+P233-P405-P501-P309
2-Bromoacetophenone Price More Price(17)
  • Brand: Sigma-Aldrich
  • Product number: 115835
  • Product name : 2-Bromoacetophenone
  • Purity: 98%
  • Packaging: 5g
  • Price: $33.6
  • Updated: 2021/03/22
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  • Brand: Sigma-Aldrich
  • Product number: 115835
  • Product name : 2-Bromoacetophenone
  • Purity: 98%
  • Packaging: 100g
  • Price: $79.1
  • Updated: 2021/03/22
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  • Brand: TCI Chemical
  • Product number: A5508
  • Product name : Phenacyl Bromide [for HPLC Labeling]
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 5g
  • Price: $29
  • Updated: 2021/03/22
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  • Brand: TCI Chemical
  • Product number: B0535
  • Product name : Phenacyl Bromide
  • Purity: >98.0%(GC)
  • Packaging: 25g
  • Price: $56
  • Updated: 2021/03/22
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  • Brand: Alfa Aesar
  • Product number: A15576
  • Product name : 2-Bromoacetophenone, 98%
  • Purity: 
  • Packaging: 25g
  • Price: $32.3
  • Updated: 2021/03/22
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2-Bromoacetophenone Chemical Properties,Usage,Production

  • Chemical Properties Off white-grey green crystaline powder
  • Uses 2-Bromoacetophenone is a brominated acteophenone derivative. 2-Bromoacetophenone has been shown to completely and irreversibly inactivate human liver aldehyde dehydrogenase (EC 1.2.1.3) isoenzymes E1 and E2. 2-Bromoacetophenone and its derivatives display some inhibitory activity on neutral protein tyrosine.inhibitors
  • Uses Preparation of crystalline esters from acids
  • Definition ChEBI: An alpha-bromoketone that is acetophenone substituted by a bromo group at position 2.
  • Synthesis Reference(s) Journal of the American Chemical Society, 76, p. 5796, 1954 DOI: 10.1021/ja01651a061
    Organic Syntheses, Coll. Vol. 2, p. 480, 1943
    Synthetic Communications, 22, p. 1923, 1992 DOI: 10.1080/00397919208021322
  • General Description A crystalline solid or a liquid with a sharp odor. Toxic by inhalation, ingestion and skin absorption. A severe eye irritant (a lachrymator). Used to make other chemicals.
  • Air & Water Reactions Reacts slowly with moisture in air to form hydrogen bromide.
  • Reactivity Profile 2-Bromoacetophenone reacts slowly with metals causing mild corrosion.
  • Health Hazard TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
  • Fire Hazard Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
  • Purification Methods Crystallise the bromide from EtOH, MeOH or pet ether (b 80-100o). [Tanner J Org Chem 52 2142 1987, Beilstein 7 IV 649.]
2-Bromoacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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  • AKOS BBS-00004003
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  • 2-BROMO ACETEPHENONE
  • Tulobuterol Impurity 8
  • 70-11-1
  • 1970-01-1
  • 70-11-0
  • 25-87-3
  • 710-11-1
  • C8H7HBrO
  • BrCH2COC6H5
  • C6H5COCH2Br
  • Building Blocks
  • Acylation