Uses
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.
Definition
ChEBI: Kinetensin is an oligopeptide comprising of nine amino acids with sequence L-Ile-L-Ala-L-Arg-L-Arg-L-His-L-Pro-L-Tyr-L-Phe-L-Leu. It was originally isolated from pepsin-treated human plasma and shares some sequence homology with the C-terminal end of neurotensin. It is a potent histamine releaser and may serve as an inflammatory mediator. It has a role as a human metabolite and a histamine releasing agent. It is a conjugate base of a kinetensin(2+).
in vivo
Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2].
IC 50
Human Endogenous Metabolite
References
[1] Mogard MH, et al. The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem Biophys Res Commun. 1986 May 14;136(3):983-8. DOI:
10.1016/0006-291x(86)90429-8[2] Sydbom A, et al. Stimulation of histamine release by the peptide kinetensin. Agents Actions. 1989 Apr;27(1-2):68-71. DOI:
10.1007/BF02222201
