ChemicalBook > CAS DataBase List > Dihydroergotoxine mesylate

Dihydroergotoxine mesylate

CAS No.8067-24-1
Chemical Name:Dihydroergotoxine mesylate
CBNumber:CB6226235
Molecular Formula:C20H29N3O5S
Formula Weight:423.53
MOL File:8067-24-1.mol

Dihydroergotoxine mesylate Property

storage temp. Store at RT
form neat
FDA UNII X3S33EX3KW
ATC code C04AE01,C04AE51

Safety

Hazard Codes :T
Risk Statements :60
Safety Statements :53-36/37/39-45
RIDADR :1544
RTECS :KE8800000
HazardClass :6.1(b)
PackingGroup :III
HS Code :3003490000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

Dihydroergotoxine mesylate Price More Price(12)

Brand: Sigma-Aldrich
Product number: C2510000
Product name : Codergocrine mesilate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: c2510000
Price: $202
Updated: 2022/05/15
Buy: Buy

Brand: Sigma-Aldrich
Product number: 1239504
Product name : Ergoloid mesylate salt
Purity:
Packaging: 300mg
Price: $400
Updated: 2022/05/15
Buy: Buy

Brand: Cayman Chemical
Product number: 24095
Product name : Ergoloid (mesylates)
Purity: ≥95%
Packaging: 25mg
Price: $32
Updated: 2022/04/27
Buy: Buy

Brand: Cayman Chemical
Product number: 24095
Product name : Ergoloid (mesylates)
Purity: ≥95%
Packaging: 50mg
Price: $57
Updated: 2022/04/27
Buy: Buy

Brand: Cayman Chemical
Product number: 24095
Product name : Ergoloid (mesylates)
Purity: ≥95%
Packaging: 100mg
Price: $101
Updated: 2022/04/27
Buy: Buy

Dihydroergotoxine mesylate Chemical Properties,Usage,Production

Description Ergoloid is a mixture of the ergot alkaloids dihydroergocornine, dihydroergocrystine, and dihydroergocryptine. It blocks reflex vasodilation and vasoconstriction induced by norepinephrine (Item No. 16673) in dogs when injected into the kidney at a dose of 0.15 mg. Ergoloid blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner. It also acts as an erectogenic agent in rats. Formulations containing ergoloid have been used in the treatment of migraine headaches and vascular dementias.
Uses Cognition adjuvant.
Definition ChEBI: A mixture of hydrogenated ergot alkaloids consisting of the methanesulfonic acid salts of dihydroergocornine (R = CHMe2), dihydroergocristine (R = CH2Ph), and alpha- and beta-dihydroer ocryptine (R = CH2CHMe2 and CH(Me)Et, respectively). It is used for the symptomatic treatment of mild to moderate dementia in the elderly, although its value is not established.
brand name Alkergot (Sandoz); Circanol(3M Pharmaceuticals); Deapril (Bristol-Myers Squibb);Gerimal (Watson); Hydergine (Novartis).
Pharmacology The metabolic effects of ergoloid mesylates (Hydergine) may include enhancement of noradrenergic, dopaminergic and serotoninergic neurotransmission (Weil,1988) and reduction of free radicals. Schneider and Olin (1994) reviewed 151 reports on the use of Hydergine in senile dementia, but only 47 of these trials (31%) met strict criteria for meta-analysis. ACochrane review (Olin et al., 2001) confirmed that patients with VaD appeared to benefit more than patients with AD in terms of cognition,clinical global ratings and combined measures. However, compared with placebo, efficacy was very modest. Thus, there are no grounds to recommend its use.