R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

Uses

R(+)-SCH-23390 hydrochloride has been used:

• for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
• as a D1 receptor-selective antagonist for intracranial drug infusions
• as an antagonist of D1 receptor to study its effect on learning ability in fish

Uses

A selective dopamine D1 receptor antagonist.

Biological Activity

Potent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro .

Biochem/physiol Actions

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

storage

+4°C (desiccate)