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Bromocriptine Structure

Bromocriptine

Chemical Properties

Melting point 215-218° (dec)
alpha  D20 -195° (c = 1 in methylene chloride)
Boiling point 891.3±65.0 °C(Predicted)
Density  1.2734 (rough estimate)
refractive index  1.6400 (estimate)
pka pKa 4.90±0.05(80% MCS t = RT) (Uncertain)
Water Solubility  2.07mg/L(temperature not stated)
CAS DataBase Reference 25614-03-3(CAS DataBase Reference)
FDA UNII 3A64E3G5ZO
ATC code G02CB01,N04BC01
NCI Drug Dictionary Parlodel

Safety

Symbol(GHS)
Signal wordWarning
Hazard statements H361-H362-H302
Precautionary statements P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P201-P260-P263-P264-P270-P308+P313
Toxicity An ergot alkaloid derivative that exhibits potent dopamine agonist properties, particularly at D2 dopamine receptors. Bromocriptine, like dopamine, inhibits prolactin release from the pituitary and so is used in endocrine disorders, such as hyperprolactinemia. It is also used in the treatment of Parkinson’s disease. A large “first-pass” effect is seen with bromocriptine, and peak concentrations occur about 1.5-3 h after ingestion, with a half-life of about 3 h. Nausea, vomiting, and orthostatic hypotension are among the acute adverse effects. Long-term use has been associated with dyskinesias, constipation, psychoses, digital spasm, and erythromelalgia. The LD50 in rabbits exceeds 1 g/kg, p.o., and 12 mg/kg, i.v.

Bromocriptine Chemical Properties,Usage,Production

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