Sodium pentachlorophenolate Property
- Melting point: :>300°C
- CAS DataBase Reference :131-52-2(CAS DataBase Reference)
- FDA 21 CFR :178.3900; 175.105; 176.170; 176.200; 176.300; 177.2600; 177.2800; 178.3120
- Indirect Additives used in Food Contact Substances :SODIUM PENTACHLOROPHENATE
- EWG's Food Scores :4
- FDA UNII :640L8FZO38
- EPA Substance Registry System :Sodium pentachlorophenate (131-52-2)
- Signal word
- Hazard statements
- Precautionary statements
Sodium pentachlorophenolate Chemical Properties,Usage,Production
- Description Pentachlorophenol (PCP) can be found in two forms: pentachlorophenol itself or as the sodium salt of pentachlorophenol (NaPCP). These two forms have some different physical properties, but are expected to have similar toxic effects. PCP is a synthetic substance, made from other chemicals, and does not occur naturally in the environment. Although PCP was first synthesized in 1841, it was not produced commercially until 1936. It has since been registered for use as an insecticide, fungicide, herbicide, algicide, and disinfectant. By 1967, PCP and its sodium salt, NaPCP, were used extensively in industry and agriculture, due in large part to the solubility of PCP in organic solvents and of NaPCP in water. In 1977, both were listed together as the second most heavily used pesticide in the United States.
- Chemical Properties Sodium pentachlorophenate is a crystalline solid. Phenolic odor.
- Chemical Properties White or tan powder. Soluble in water, ethanol, and acetone; insoluble in benzene.
- Uses Fungicide; herbicide; slimicide; fermentation disinfectant, especially in finishes and papers.
- Uses PCP and its water soluble salt, NaPCP, are commercially produced organochlorine compounds used primarily as the preservatives of wood and wood products, and secondarily as herbicides, insecticides, fungicides, molluscicides, and bactericides.
- General Description Sodium pentachlorophenolate is a white or tan, powdered solid. Sodium pentachlorophenolate is soluble in water and may burn, but Sodium pentachlorophenolate is not easily ignited. Sodium pentachlorophenolate may be toxic by ingestion, inhalation and skin absorption. Sodium pentachlorophenolate is used as a fungicide, herbicide and as a disinfectant.
- Air & Water Reactions Soluble in water.
- Reactivity Profile Sodium pentachlorophenolate is incompatible with strong oxidizing agents.
- Hazard Toxic by ingestion, inhalation; skin irritant.
- Health Hazard Exposure can cause irritation of eyes, nose and throat. May cause weakness, excessive sweating, headache, dizziness, nausea, vomiting, and difficulty in breathing.
- Fire Hazard Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as hydrogen chloride, polychlorodibenzodioxins and carbon monoxide, may be formed when involved in fire.
- Safety Profile Poison by ingestion, inhalation, skin contact, intravenous, intraperitoneal, subcutaneous, and intratracheal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland Na2O. See also CHLOROPHENOLS.
- Potential Exposure Uses include: wood preservative; as a fungicide in water-based latex paints; preservation of cellulose products, textiles, adhesives, leather, pulp, paper, and industrial waste systems; a contact and preemergence herbicide; general disinfectant and control of the intermediate snail host of schistosomiasis. The technical grade of sodium pentachlorophenate usually contain toxic microcontaminants including polychlorinated dibenzodioxins and dibenzofurans (132-64-9, and others).
- Carcinogenicity Data from a wide range and large number of studies evaluating the carcinogenic potential of pentachlorophenol are available. These include three longterm carcinogenicity studies in mice, three in rats, two studies evaluating the potential of pentachlorophenol to act as promoter in the carcinogenic process, and a “stop exposure” study. The results of the initiation and/or promotion studies are uniformly negative, as are the results of all the rat studies and two of the three long-term mouse studies. In addition, a very large body of genotoxicity evidence suggests that pentachlorophenol is nonmutagenic.
Routes and pathways, relevant physicochemical properties
Solubility: in water 330 g l-1 at 25 °C; soluble in ethanol,
acetone; insoluble in benzene and petroleum oils.
Partition behavior in water, sediment, and soil
If released to air, NaPCP will exist solely in the aerosol
phase in the ambient atmosphere. The aerosol phase will be
removed from the atmosphere by wet and dry deposition. If released to soil and water under typical ambient conditions
(pH 5–9), NaPCP is expected to exist predominately in
its dissociated form (pKa 4.7). Releases to soil can decrease
in concentration due to slow biodegradation (half-life is
weeks to months) and leaching into groundwater. Releases
to water may photolyze (half-life is hours to days with
rate decreasing with depth of water), biodegrade, adsorb
to sediments, or bioaccumulate in aquatic organisms.
Biodegradation probably becomes significant after a period
NaPCP is not persistent in water, sewage, or soil because of bacterial decomposition. PCP readily decomposes in sunlight to monomeric and dimeric oxidation products in water. Principal decompose products are tetrachlororesorcinol, chloranilic acid, and dimeric products.
Bioaccumulation and biomagnification
Sodium pentachlorophenol did not appear to bioaccumulate in aquatic organisms to very high concentrations. BCFs for the compound were <1000 for most species tested.
- Shipping UN2567 Sodium pentachlorophenate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
- Toxicity evaluation The biochemical action of pentachlorophenol is active uncoupling of oxidation phosphorylation. PCP binds to mitochondrial protein and inhibits mitochondrial ATP-ase activity. Thus, both the formation of ATP and the release of energy to the cell from the breakdown of ATP to ADP are prevented. Electron transport is not inhibited by PCP, although reactions dependent on available high-energy bonds, such as oxidative and glycolytic phosphorylation, are affected. Binding to enzymatic protein has been reported and may lead to the inhibition of other cellular enzymes. There is also an increase in cellular oxygen demand during the uncoupling of oxidative phosphorylation. This causes the initial rise in respiration rate reported in individuals poisoned by PCP.
- Incompatibilities Uses include: wood preservative; as a fungicide in water-based latex paints; preservation of cellulose products, textiles, adhesives, leather, pulp, paper, and industrial waste systems; a contact and preemergence herbicide; general disinfectant and control of the intermediate snail host of schistosomiasis. The technical grade of sodium pentachlorophenate usually contain toxic microcontaminants including polychlorinated dibenzodioxins and dibenzofurans (132-64-9, and others).
- Waste Disposal Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.
Sodium pentachlorophenolate Preparation Products And Raw materials
131-52-2, Sodium pentachlorophenolateRelated Search:
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