Chemical Properties
Crystalline powder. Very soluble in chloroform and carbon tetrachloride; slightly
soluble in water.
Definition
ChEBI: Famphur is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an agrochemical and an anthelminthic drug. It is functionally related to a 4-hydroxy-N,N-dimethylbenzenesulfonamide.
General Description
Crystalline powder. Very toxic. Cholinesterase inhibitor. Restricted use as insecticide.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
Organothiophosphates, such as FAMPHUR, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Hazard
Cholinesterase inhibitor, use may be
restricted.
Metabolism
The principal degradation routes in mammals are P?Ophenyl
bond cleavage and O-demethylation. Oxidative
desulfuration and N-demethylation also take place to form
toxic metabolites.
Toxicity evaluation
The acute oral LD
50 for rats is 35–62 mg/kg.
