Uses
1-Phenylbiguanide is a 5-hydroxytryptamine receptor agonist.
Definition
ChEBI: A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a phenyl group.
General Description
1-Phenylbiguanide is a 5-hydroxytryptamine receptor agonist and increases extracellular dopamine release in rat nucleus accumbens
in vivo. It serves as building block for synthesis of heterocyclic compounds.
in vivo
In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression[3].
IC 50
5-HT
3 Receptor: 3 μM (EC
50)
Purification Methods
Crystallise the biguanide from water or toluene. [Beilstein 12 H 370, 12 I 236, 12 III 807.]
