Description
Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC
50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .
1 TαMCA is common in rodents but has also been found in small amounts in human serum.
2
References
1. Sayin, S.I., Wahlstr?m, A., Felin, J., et al.
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist Cell Metab. 17(2),225-235(2013).
2. García-Ca?averas, J.C., Donato, M.T., Castell, J.V., et al.
Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method J. Lipid Res. 53(10),2231-2241(2012).
