ChemicalBook CAS DataBase List 5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide

5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide

Product Name5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide
CAS1245626-05-4
CBNumberCB52750957
MFC26H23Cl2N5O3S
MW556.46
MDL NumberMFCD19053178
MOL File1245626-05-4.mol
MSDS FileSDS

Chemical Properties

storage temp.	2-8°C
solubility	DMSO: >25mg/mL
form	powder
color	white to off-white
InChIKey	XBHQLFVDGLPBCK-UHFFFAOYSA-N
SMILES	Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(cc3)C#CCCC#N)C(=O)NN4CCS(=O)(=O)CC4
UNSPSC Code	12352200
NACRES	NA.77

Safety

Symbol(GHS)

Signal word

Warning

Hazard statements

H319

Precautionary statements

P305+P351+P338

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2

NFPA 704:

	0
2		0

5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich A1987	5mg	$304	AM6545 ≥98% (HPLC)	Buy
Sigma-Aldrich A1987	25mg	$968	AM6545 ≥98% (HPLC)	Buy
Cayman Chemical 16316	1mg	$44	AM6545 ≥98%	Buy
Cayman Chemical 16316	5mg	$161	AM6545 ≥98%	Buy
Cayman Chemical 16316	10mg	$235	AM6545 ≥98%	Buy

5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide Chemical Properties,Usage,Production

Uses

AM 6545 is a novel CB1 antagonist which suppresses food intake and food-motivated behaviours. Potential for use as an appetite suppressant.

Biological Activity

AM6545 helps in decreasing the development of albuminuria, inflammation and expression of markers of fibrosis. It also helps in the down-regulation of nephrin and podocin. It has the ability to repress the ingestion of food and food-reinforced behaviour.', 'AM6545 is a peripheral CB1 cannabinoid receptor antagonist and appetite suppressant.

in vivo

AM6545 (5-20 mg/kg; i.p.; once daily; 7 days or single dose) reduces food intake and sustaines body weight in Sprague Dawley rats at 10 and 20 mg/kg when treated chronically or acutely^[1].
AM6545 (10 mg/kg; ip; single dose) treatment of C57BL/6 J mice specifically induces PKA signaling activation in adipose tissue and upregulated Akt-mTOR and ERK phosphorylation levels^[2].

AM6545 (10 mg/kg; i.p.; once daily; 4 weeks) significantly improves renal function, inhibited proteinuria, uric acid excretion and renal fibrosis in a rat model of metabolic syndrome^[3].

Animal Model:	Sprague Dawley rats (male, 250-275 g; normal/high-fat diet models)^[1]
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg (4% DMSO, 1% Tween 80 in saline)
Administration:	Intraperitoneal injection, daily for 7 days or single dose.
Result:	Reduced food intake (30% inhibition at 3 h) and body weight gain (days 4-7) at 10 mg/kg dose, without inducing conditioned taste avoidance or gaping.

Animal Model:	Metabolic syndrome rats (male, Wistar; high-fructose/high-salt diet-induced)^[3]
Dosage:	10 mg/kg (0.5% carboxymethylcellulose)
Administration:	Intraperitoneal injection, daily for 4 weeks
Result:	Reduced proteinuria (50%) and urinary uric acid (attenuated 10-fold increase), alleviated glomerular hypertrophy, tubular injury, and collagen deposition, and suppressed renal TGFβ1 expression.

Animal Model:	C57BL/6 mice (male, 18.5-21.0 g; normal diet)^[2]
Dosage:	10 mg/kg (4% DMSO, 10% Tween 80, 80-95% saline)
Administration:	Intraperitoneal injection, single.
Result:	Significantly modified p-PKA substrates in adipose and liver tissue, but the responsive substrates are tissue-specific and remain to be determined Upregulated ERK1 phosphorylation at Thr202 in WAT, liver, TA. Upregulated p-Akt(Ser473) and p-mTOR(Ser2448) in liver.

storage

Store at +4°C

Preparation Products And Raw materials

5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30227	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9803	58
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	9532	58
BOC Sciences	--	info@bocsci.com	USA	0	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Suzhou Chenrui Biotechnology Co. LTD	17625585511	1580084073@qq.com	China	995	58

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5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide Spectrum

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