Biological Activity
kif15-in-2, a potent kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].kif15,also known as kinesin-12 and hklp2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.kif15 is involved in maintainingbipolar microtubulespindle apparatusin dividing cells and shares redundant functions withkif11 [3].
References
[1]. preparation of quinazolinediones as kif15 kinesin inhibitors for treating cellular proliferative disorders. pat. appl. publ. (2004), us 20040053948 a1 20040318.
[2]. buster d w, baird d h, yu w, et al. expression of the mitotic kinesin kif15 in postmitotic neurons: implications for neuronal migration and development[j]. journal of neurocytology, 2003, 32(1): 79-96.
[3]. vanneste d, takagi m, imamoto n, et al. the role of hklp2 in the stabilization and maintenance of spindle bipolarity[j]. current biology, 2009, 19(20): 1712-1717.
