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DESACETYLVINBLASTINEAMIDE

DESACETYLVINBLASTINEAMIDE Structure
DESACETYLVINBLASTINEAMIDE
  • CAS No.53643-48-4
  • Chemical Name:DESACETYLVINBLASTINEAMIDE
  • CBNumber:CB5266881
  • Molecular Formula:C43H55N5O7
  • Formula Weight:753.93
  • MOL File:53643-48-4.mol
DESACETYLVINBLASTINEAMIDE Property
  • Melting point: :230-232°
  • alpha  :D25 +39.4° (c = 1.0 in methanol)
  • pka :pKa (DMF 66%) 5.39, 7.36; (H2O) 6.04, 7.67(at 25℃)
  • FDA UNII :RSA8KO39WH
  • NCI Dictionary of Cancer Terms :vindesine
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

DESACETYLVINBLASTINEAMIDE Chemical Properties,Usage,Production

  • Originator Eldisine,Lilly ,France,1980
  • Uses Antineoplastic.
  • Manufacturing Process About 10 g of VLB (vincaleucoblastine or simply vinblastine) sulfate were converted by standard procedures to VLB free base. The free base, obtained as a residue after evaporation of the dried ethereal solvent, was dissolved in about 200 ml of anhydrous methanol. Anhydrous liquid ammonia (300 ml) was added, and the reaction mixture sealed and maintained at about 100°C for 60 hours. The reaction vessel was opened, and the contents removed and evaporated to dryness in vacuo. The resulting residue, containing 4-desacetyI VLB C-3 carboxamide, as shown by thin layer chromatography, were combined and the solvent evaporated therefrom in vacuo, yielding asa residue purified 4-desacetyl VLB C-3 carboxamide free base. The NMR and IR spectra of the solid free base confirmed the structure indicated. The free base showed a band in the infrared at 1,687 cm -l , characteristic of the amide function. The molecular weight of the free base determined by mass spectroscopy was 753 which is in agreement with theoretical value calculated for C 43 H 55 N 5 O 7 .
  • brand name Eldisine (Lilly).
  • Therapeutic Function Antineoplastic
DESACETYLVINBLASTINEAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
DESACETYLVINBLASTINEAMIDE Suppliers
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53643-48-4, DESACETYLVINBLASTINEAMIDERelated Search:
  • VINDESINE
  • 3-(aminocarbonyl)-o(sup4)-deacetyl-3-de(methoxycarbonyl)-vincaleukoblastin
  • 3-(aminocarbonyl)-o(sup4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
  • DESACETYLVINBLASTINEAMIDE
  • Fildesin
  • Compound 112531:NS C.245467:LY-099094:Hdisine:Fildisin
  • VDS
  • Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-
  • VINDESINE SULFATE(RG)
  • 3-(Aminocarbonyl)-O^<4>^-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
  • 3-(Aminocarbonyl)-4-O-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
  • 3-Carbamoyl-4-O-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
  • Compound-112531
  • Eldesine
  • DESACETYLVINBLASTINEAMIDE USP/EP/BP
  • 53643-48-4
  • C43H55N5O7