KN92 phosphate

Uses

KN-92 is a useful negative control for KN-93.

General Description

Useful as a negative control for KN-93 (Cat. No. 422708), a Ca²⁺/CaM kinase II inhibitor.

Biological Activity

kn-92 is the inactive analog of ca2+/calmodulin-dependent kinase ii (camkii) inhibitor kn-93. kn-92 has been often used as negative control for kn-93.kn-92 significantly reduced the sustained current amplitudes at the end of the 5-s depolarizing pulses of a wide range of kv channels such as kv1.5 and kv1.2 [1].

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

References

[1]. rezazadeh s, claydon tw, fedida d.kn-93(2-[n-(2-hydroxyethyl)]-n-(4-methoxybenzenesulfonyl)]amino-n-(4-chlorocinnamyl)-n-methylbenzylamine), a calcium/calmodulin-dependent protein kinase ii inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.j pharmacolexpther. 2006 apr;317(1):292-9.