BrettPhosPalladacycle

Reaction

1. Catalyst for cross-coupling reactions using aryl mesylates with electron-deficient anilines.
2. Catalyst for rapid C-N bond-forming processes at low catalyst loading.
3. Cross-coupling of 3-Bromo-2-aminopyridine with primary amines.

Uses

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Catalyst for:

• C,N-cross coupling of unprotected 3-halo-2-aminopyridines with primary and secondary amines
• Amination reaction
• N-arylation of aminophenols

General Description

BrettPhos Pd G1 is a Buchwald first generation (G1) palladacycle precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The formation of the active Pd(0) species in the G1 precatalyst is easy to generate, requiring merely a deprotonation with a base. The resulting catalyst is very active, even at temperatures down to ?40 °C, and can be used in a variety of cross-coupling protocols.