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Alpelisib (BYL719)

 Alpelisib (BYL719) Structure
Alpelisib (BYL719)
  • CAS No.1217486-61-7
  • Chemical Name: Alpelisib (BYL719)
  • CBNumber:CB52604234
  • Molecular Formula:C19H22F3N5O2S
  • Formula Weight:441.47
  • MOL File:1217486-61-7.mol
Alpelisib (BYL719) Property
  • Density  :1.391
  • form  :White solid.
  • pka :6.29±0.70(Predicted)
  • FDA UNII :08W5N2C97Q
  • NCI Dictionary of Cancer Terms :alpelisib
  • NCI Drug Dictionary :alpelisib
  • ATC code :L01EM03
Safety
  • HS Code  :29341000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Alpelisib (BYL719) Price More Price(40)
  • Brand: Cayman Chemical
  • Product number: 16986
  • Product name : BYL719
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $42
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 16986
  • Product name : BYL719
  • Purity: ≥98%
  • Packaging: 10mg
  • Price: $80
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: M331055
  • Product name : (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • Purity: 
  • Packaging: 25mg
  • Price: $190
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: ApexBio Technology
  • Product number: A8346
  • Product name : BYL-719
  • Purity: 
  • Packaging: 20mg
  • Price: $200
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Biosynth Carbosynth
  • Product number: FP71607
  • Product name : BYL 719
  • Purity: 
  • Packaging: 10 mg
  • Price: $95
  • Updated: 2021/12/16
  • Buy: Buy

Alpelisib (BYL719) Chemical Properties,Usage,Production

  • Description BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.
  • Uses (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibit or for the treatment of proliferative diseases.
  • Uses (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibitor for the treatment of proliferative diseases.
Alpelisib (BYL719) Preparation Products And Raw materials
Raw materials
Preparation Products
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1217486-61-7, Alpelisib (BYL719)Related Search:
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • BYL-719
  • BYL-719 /BYL719
  • Alpelisib
  • BLV-719
  • (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide
  • ALPELISIB;BYL-719; BYL 719
  • CS-614
  • Alpelisib - NVP-BYL719 | BYL-719
  • 100803
  • (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
  • 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-
  • Alpelisib (BYL719)
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719
  • BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • BYL-719(Alpelisib)
  • (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolid
  • Alpelisib, 98%, a potent and selective PI3Kα inhibitor
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ISO 9001:2015 REACH
  • Alpelisib (BLY-719
  • Piqray
  • 1217486-61-7
  • C19H22F3N5O2S
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
  • Api
  • PI3K/Akt/mTOR
  • API