2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester

Description

Butyrolactone II is a butenolide fungal metabolite that has been found in A. terreus. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS free radicals (EC₅₀s = 11.5 and 68.5 μM, respectively). It inhibits 5-lipoxygenase (5-LO; IC₅₀ = 21.43 μg/ml) and α-glucosidase (IC₅₀ = 0.126 mM).

Uses

Butyrolactone II is an antibiotic, a 5-LOX inhibitor and has shown DPPH radical-scavening activity.

IC 50

Microbial Metabolite

storage

+4°C

References

[1] HAHK-SOO KANG  Jong P K. Butenolide derivatives from the fungus Aspergillus terreus and their radical scavenging activity and protective activity against glutamate-induced excitotoxicity[J]. Applied Biological Chemistry, 2019, 62 1. DOI: 10.1186/s13765-019-0451-3
[2] FU-SHENG WANG B Z. Butyrolactones, inhibitors of 5-lipoxygenase from fungal metabolites[J]. Journal of Chinese Pharmaceutical Sciences, 2010, 19 1. DOI: 10.5246/jcps.2010.04.035
[3] LI-HUA ZHANG . Polyketide butenolide, diphenyl ether, and benzophenone derivatives from the fungus Aspergillus flavipes PJ03-11[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 2: Pages 346-350. DOI: 10.1016/j.bmcl.2015.12.009