ChemicalBook > CAS DataBase List > 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide

1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide

1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Structure
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
  • CAS No.722456-31-7
  • Chemical Name:1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
  • CBNumber:CB51977298
  • Molecular Formula:C18H12N6OS
  • Formula Weight:360.39
  • MOL File:722456-31-7.mol
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Property
  • Boiling point: :627.0±65.0 °C(Predicted)
  • Density  :1.53±0.1 g/cm3(Predicted)
  • storage temp.  :room temp
  • solubility  :DMSO: ≥5mg/mL
  • form  :Tan solid
  • pka :0.85±0.30(Predicted)
  • color  :white to beige
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Price More Price(32)
  • Brand: Sigma-Aldrich
  • Product number: SML0273
  • Product name : VAS2870
  • Purity: ≥97% (HPLC)
  • Packaging: 5mg
  • Price: $78.2
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 492000-M
  • Product name : NOX Inhibitor III, VAS2870
  • Purity: 
  • Packaging: 10mg-m
  • Price: $135
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 492000-M
  • Product name : NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem
  • Purity: The NOX Inhibitor III, VAS2870, also referenced under CAS 722456-31-7, controls the biological activity of NOX.
  • Packaging: 10 mg
  • Price: $135
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19205
  • Product name : VAS2870
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $63
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19205
  • Product name : VAS2870
  • Purity: ≥98%
  • Packaging: 1mg
  • Price: $25
  • Updated: 2021/12/16
  • Buy: Buy

1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Chemical Properties,Usage,Production

  • Uses VAS 2870, is a NADPH oxidase (NOX) inhibitor.
  • General Description
    A cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC50 = 10.6 μM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 μM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 μM), as well as aortic sections from spontaneously hypertensive rats (SHRs) (72% inhibition at 10 μM). Also shown to inhibit PDGF-BB-induced murine EB (embryonid body) vacularization (74% inhibition at 50 μM) and improve ACh-induced vasorelaxation of isolated rat aortic rings from both SHRs and non-hypertensive rats ex vivo (by 41.7 and 34.5%, respectively, at 10 μM).
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Preparation Products And Raw materials
Raw materials
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722456-31-7, 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfideRelated Search:
  • 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
  • 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine
  • 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
  • VAS 2870
  • VAS2870
  • VAS-2870
  • NOX Inhibitor III, VAS2870
  • 2-(3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylthio)benzo[d]oxazole
  • NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem
  • VAS 2870;VAS-2870;VAS2870
  • 3H-1,2,3-Triazolo[4,5-d]pyrimidine, 7-(2-benzoxazolylthio)-3-(phenylmethyl)-
  • 722456-31-7
  • 722546-31-7
  • C18H12N6OS