Chemical Properties
Off-white needle-like crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Oxtail Duhuo.
Uses
Sphondin has an Analgesic, anti-inflammatory, anti-allergic, smooth muscle spasmolytic effect.
Definition
ChEBI: Sphondin is a furanocoumarin.
Biological Activity
Sphondin, isolated from Heracleum laciniatum, has inhibitory effects on IL-1β-induced increases in COX-2 protein and PGE2 release levels in A549 cells.
in vitro
Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE 2 release.
