Uses
4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.', 'AYPGKF- NH2 may be used for probing PAR4 signaling in culture systems and in platelets.
Biological Activity
AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation. Additionally, AYPGKF mediates the thrombin-induced release of endostatin from r at platelets.
