Description
Prostaglandin J
2 (PGJ
2) is formed from PGD
2 by the elimination of the C-
9 hydroxyl group, a process which is accelerated by the presence of albumin. PGJ
2 inhibits platelet aggregation with an IC
50 of about 5-
10 nM. PGJ
2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines. However, this activity has been attributed to further metabolites of PGJ
2 and not the parent compound itself.
Definition
ChEBI: A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).
