Description References
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N,N-Dimethylglycine

Description References
N,N-Dimethylglycine Structure
N,N-Dimethylglycine
  • CAS No.1118-68-9
  • Chemical Name:N,N-Dimethylglycine
  • CBNumber:CB4440420
  • Molecular Formula:C4H9NO2
  • Formula Weight:103.12
  • MOL File:1118-68-9.mol
N,N-Dimethylglycine Property
  • Melting point: :178-182 °C(lit.)
  • Boiling point: :193.35°C (rough estimate)
  • Density  :1 g/cm3
  • refractive index  :1.4674 (estimate)
  • storage temp.  :Keep in dark place,Sealed in dry,Room Temperature
  • pka :9.89(at 25℃)
  • form  :Crystalline Powder
  • color  :White to slightly yellow
  • Water Solubility  :soluble
  • Sensitive  :Hygroscopic
  • Merck  :14,3244
  • BRN  :1700261
  • InChIKey :FFDGPVCHZBVARC-UHFFFAOYSA-N
  • CAS DataBase Reference :1118-68-9(CAS DataBase Reference)
  • EWG's Food Scores :1
  • FDA UNII :7797M4CPPA
  • EPA Substance Registry System :Glycine, N,N-dimethyl- (1118-68-9)
Safety
  • Hazard Codes  :Xn,Xi
  • Risk Statements  :22-36/37/38
  • Safety Statements  :24/25-36/37-26
  • WGK Germany  :3
  • RTECS  :MB9865000
  • F  :3
  • TSCA  :Yes
  • HazardClass  :IRRITANT
  • HS Code  :29224999
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312a-P330-P501a-P264-P270-P301+P312+P330-P501
N,N-Dimethylglycine Price More Price(12)
  • Brand: Sigma-Aldrich
  • Product number: 05022
  • Product name : N,N-Dimethylglycine
  • Purity: for HPLC derivatization, ≥99% (NT)
  • Packaging: 1g
  • Price: $55.2
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 05022
  • Product name : N,N-Dimethylglycine
  • Purity: for HPLC derivatization, ≥99% (NT)
  • Packaging: 10x1g
  • Price: $407
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: D3585
  • Product name : N,N-Dimethylglycine
  • Purity: >98.0%(T)
  • Packaging: 5g
  • Price: $52
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: D3585
  • Product name : N,N-Dimethylglycine
  • Purity: >98.0%(T)
  • Packaging: 25g
  • Price: $154
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: A19670
  • Product name : N,N-Dimethylglycine, 98+%
  • Purity: 
  • Packaging: 5g
  • Price: $63
  • Updated: 2021/03/22
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N,N-Dimethylglycine Chemical Properties,Usage,Production

  • Description N,N-Dimethylglycine (DMG) is a N-methylated product of the amino acid glycine. It is found in beans and liver. It is used in comparative analysis with other N-methylated glycines. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers, and as a substrate to identify, differentiate and characterize amino acid methyltransferase(s). It can be used also as an athletic performance enhancer, immunostimulant, and to treat autism, epilepsy, or mitochondrial disease. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients.
  • References J. K. Kern, V. S. Miller, L. Cauller, R. Kendall, J. Mehta, M. Dodd, Effectiveness of N,N-Dimethylglycine in Autism and Pervasive Developmental Disorder, Journal of Child Neurology, 2001, vol. 16, pp. 169-173
  • Description Dimethyl glycine (DMG) is a derivative of the amino acid glycine with the structural formula (CH3)2NCH2COOH. It can be found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline.
    When DMG was first discovered, it was referred to as vitamin B16, but, unlike true B vitamins, deficiency of DMG in the diet does not lead to any ill-effects meaning it does not meet the definition of a vitamin.
  • Chemical Properties white to slightly yellow crystalline powder
  • Uses Dimethylglycine has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease . Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.
  • Preparation N,N-Dimethylglycine is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may been obtained by neutralization of the acid salt, which has been performed with silver oxide.
    H2NCH2COOH + 2 CH2O + 2 HCOOH →(CH3)2NCH2COOH + 2 CO2 + 2 H2O.
  • Definition ChEBI: An N-methylglycine that is glycine carrying two N-methyl substituents.
N,N-Dimethylglycine Preparation Products And Raw materials
Raw materials
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