ILK-IN-2
- Product NameILK-IN-2
- CAS2070015-22-2
- CBNumberCB43121106
- MFC30H30F3N5O
- MW533.59
- MOL File2070015-22-2.mol
Chemical Properties
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO: ≥ 50 mg/mL (93.70 mM); Water: < 0.1 mg/mL (insoluble) |
| form | Solid |
| color | White to off-white |
ILK-IN-2 Chemical Properties,Usage,Production
Uses
OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain)[1]. OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner[2]. OSU-T315 causes cell death through apoptosis and autophagy[1].in vivo
OSU-T315 (Oral gavage; 25 mg/kg, 50 mg/kg; single daily; 35 days) has a suppressive effect of on PC-3 xenograft tumor growth [1].
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No other obvious toxicity is observed in mice[1].
| Animal Model: | Male NCr athymic nude mice with PC-3 tumor xenografts |
| Dosage: | 25 mg/kg; 50 mg/kg |
| Administration: | Oral gavage; single daily; 35 days |
| Result: | Resulted in suppression of tumor growth relative to the vehicle control after 35 days of treatment (48% and 62% suppression for 25 and 50 mg/kg, respectively). |
References
[1] Su-Lin Lee,et al Identification and Characterization of a Novel Integrin-Linked Kinase Inhibitor.J Med Chem. 2011 Sep 22; 54(18): 6364–6374 DOI:10.1021/jm2007744[2] Liu TM, et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 2015 Jan 8;125(2):284-95. DOI:10.1182/blood-2014-06-583518
Preparation Products And Raw materials
ILK-IN-2 Suppliers
Global(43)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 | |
| +17819995354 | marketing@targetmol.com | United States | 32281 | 58 | |
| +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 | |
| support@targetmol.com | United States | 38665 | 58 | ||
| +86-18341751992 +86-15382112998 |
757984502@qq.com | China | 892 | 58 | |
| tp@aladdinsci.com | United States | 52924 | 58 | ||
| 028-81700200 18116577057 |
3003855609@qq.com | China | 7787 | 56 | |
| 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 | |
| 021-65675885 18964387627 |
info@efebio.com | China | 9803 | 58 | |
| 021-61312847; 18021002903 |
3008007409@qq.com | China | 71826 | 60 |
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