Description
Lipoamido-PEG8-acid contains a lipoic acid group and a carboxylic acid moiety. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Lipoic acid contains two sulfur atoms (at C6 and C8) connected by a disulfide bond and is thus considered to be oxidized although either sulfur atom can exist in higher oxidation states. The hydrophilic PEG linker increases the water solubility of the compound.
reaction suitability
reaction type: Pegylations
reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: gold reactive
