FMoc-NH-5(ethylene glycol)-acetic acid
- Product NameFMoc-NH-5(ethylene glycol)-acetic acid
- CAS635287-26-2
- CBNumberCB42546850
- MFC27H35NO9
- MW517.57
- MDL NumberMFCD26142982
- MOL File635287-26-2.mol
- MSDS FileSDS
Chemical Properties
| Boiling point | 704.3±60.0 °C(Predicted) |
| Density | 1.224±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 3.39±0.10(Predicted) |
FMoc-NH-5(ethylene glycol)-acetic acid Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| AK Scientific 0364AP | 250mg | $303 | Fmoc-NH-PEG5-CH2COOH |
Buy |
| ChemPep 280104 | 1g | $306 | Fmoc-NH-PEG5-CH2COOH |
Buy |
| Activate Scientific AS103968 | 1g | $413 | FmocNH-PEG5-CH2COOH 95+% |
Buy |
| Apolloscientific BIPG1412 | 500mg | $607 | Fmoc-NH-PEG5-CH2COOH |
Buy |
| chempep 280104 | 5g | $820 | Fmoc-NH-PEG5-CH2COOH >=95% |
Buy |
FMoc-NH-5(ethylene glycol)-acetic acid Chemical Properties,Usage,Production
Description
Fmoc-NH-PEG5-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.Biological Activity
Fmoc-NH-PEG5-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Cleavable
| Alkyl/ether
| PEGs
|
Preparation Products And Raw materials
FMoc-NH-5(ethylene glycol)-acetic acid Supplier
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sales@molcore.com | China | 49739 | 58 |
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