Oral drug for the treatment of multiple sclerosis
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Fingolimod hydrochloride

Oral drug for the treatment of multiple sclerosis
Fingolimod hydrochloride Structure
Fingolimod hydrochloride
  • CAS No.162359-56-0
  • Chemical Name:Fingolimod hydrochloride
  • CBNumber:CB4244536
  • Molecular Formula:C19H34ClNO2
  • Formula Weight:343.93
  • MOL File:162359-56-0.mol
Fingolimod hydrochloride Property
  • Melting point: :102-107°C
  • storage temp.  :-20°C Freezer
  • solubility  :water: soluble10mg/mL, clear
  • form  :powder
  • color  :white to beige
  • Merck  :14,4083
  • InChIKey :SWZTYAVBMYWFGS-UHFFFAOYSA-N
  • CAS DataBase Reference :162359-56-0(CAS DataBase Reference)
  • EWG's Food Scores :1
  • FDA UNII :G926EC510T
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38-52/53
  • Safety Statements  :26-61
  • WGK Germany  :3
  • RTECS  :TY3130000
  • HS Code  :29221990
  • Toxicity :LD50 orally in rats: 300-600 mg/kg (Troncoso)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335-H412
  • Precautionary statements P261-P273-P305+P351+P338
Fingolimod hydrochloride Price More Price(8)
  • Brand: Sigma-Aldrich
  • Product number: SML0700
  • Product name : FTY720
  • Purity: ≥98% (HPLC)
  • Packaging: 5mg
  • Price: $59.9
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: SML0700
  • Product name : FTY720
  • Purity: ≥98% (HPLC)
  • Packaging: 25mg
  • Price: $244
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: F1018
  • Product name : Fingolimod Hydrochloride
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 200mg
  • Price: $115
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: F1018
  • Product name : Fingolimod Hydrochloride
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 1g
  • Price: $389
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 10006292
  • Product name : Fingolimod (hydrochloride)
  • Purity: ≥98%
  • Packaging: 50mg
  • Price: $49
  • Updated: 2020/06/24
  • Buy: Buy

Fingolimod hydrochloride Chemical Properties,Usage,Production

  • Oral drug for the treatment of multiple sclerosis Fingolimod hydrochloride is the first oral drug for the treatment of multiple sclerosis. It is successfully developed by the pharmaceutical company Novartis, and it has been approved for marketing by the US Food and Drug Administration (FDA). The recommended dose is 0.5mg once a day for oral administration.
    Multiple sclerosis is a debilitating neurological disease that can cause the patient to lose a sense of balance, appear muscle spasms and other movement disorders. The disease has been treated with injectable drugs. This kind of medication brought great inconvenience to patients.
    Fingolimod is a sphingosine-l-phosphate (S1PR) receptor modulator. After phosphorylation, It is bound to s1P receptor that is on the surface of lymphocyte, which will change lymphocyte migration, and promote cells into the lymphatic tissue, and prevent lymphocytes from leaving the lymphoid tissue and get into the graft. Thereby, it will prevent these cells from infiltrating the central nervous system (CNS), which achieves the effect of immunosuppression. According to the drug's introduction, drugmaker Novartis said that this process of pharmacological effects is reversible. If medication is stopped, the level of lymphocytes in circulating system will return to normal.
    The above information is edited by the chemicalbook of Kui Ming.
  • Description Approved by the U.S. FDA in September 2010, fingolimod (also referred to as FTY720) is the first approved oral therapy for the relapsing-remitting form ofmultiple sclerosis (RRMS). Because of fingolimod’s structural resemblance to sphingosine, a metabolite of sphingolipids that constitutes the cell membrane of all eukaryotic cells, it was hypothesized that fingolimod may be affecting sphingolipid metabolism in cells. A series of elegant in vitro and in vivo studies confirmed that fingolimod is converted to (S)-fingolimod phosphate primarily by sphingosine kinase- 2 and that (S)-fingolimod phosphate mediates multiple biological processes by binding to novel GPCR’s referred to as sphingosine-1-phosphate (S1P) receptors. S1P receptors are divided into five subtypes, S1P1–5, which have varying tissue and cellular distribution. S1P1–3 receptors are ubiquitously expressed in the immune, cardiovascular, and central nervous systems, S1P4 is restricted to the hematopoietic system, and S1P5 is mostly localized in the white matter of CNS. S1P1–3 receptors play important roles in endothelial barrier function, maintaining vascular tone, regulating heart rate and allowing for lymphocyte egress fromsecondary lymphoid organs. The functional role of S1P4 is unknown,while the S1P5 receptor is thought to be involved in natural killer cell trafficking and oligodendrocyte function.
  • Chemical Properties White Solid
  • Originator Yoshitomi Pharmaceutical Industries (now Mitsubishi Tanabe Pharma) (United States)
  • Uses A derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibitin
  • Uses Oral medicine for the treatment of multiple sclerosis
  • Uses FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolong s allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
  • Uses A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties.
  • Definition ChEBI: The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).
  • brand name Gilenya
Fingolimod hydrochloride Preparation Products And Raw materials
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162359-56-0, Fingolimod hydrochlorideRelated Search:
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  • Gilenya
  • Fingolimod hydrochloride, 98%, S1P antagonist
  • FTY720 hydrochloride, >=99%
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  • FingolimodHydrochloride&gt
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  • 162359-56-0
  • 62359-55-9
  • C19H34ClNO2
  • C19H33NO2HCl
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