Uses
2-Phenylmelatonin is a melatonin receptor binder with mixed agonist/antagonist activity.
Definition
ChEBI: N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide is a phenylindole.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 38, p. 1132, 1995
DOI: 10.1021/jm00007a010
Biological Activity
Highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC 50 values for G protein activation in MT 1 and MT 2 -transfected cells are 65 and 58 pM respectively.
storage
Desiccate at +4°C
