Chemical Properties
Colorless to yellow liquid or low melting solid,
Uses
Chlorotriisopropoxytitanium(IV) solution may be used as a precursor for the synthesis of ultralow density ceramic materials. The product may be used to mediate a reductive amination reaction of 5α-cholestane-3,7-dione to yield aryl aminocholestanes.
Synthesis Reference(s)
1. Reetz, M. T.; Westermann, J.; Steinbach, R.; Wenderoth, B.; Peter, R.; Ostarek, R.; Maus, S. CB 1985, 118, 1421.
reaction suitability
core: titanium
reagent type: catalyst
Synthesis
Chlorotitanium triisopropoxide can be easily made from a 3:1 mixture of Titanium Tetraisopropoxide and Titanium(IV) Chloride,
1 which can be distilled to give the pure reagent or used in situ.
Purification Methods
When distilled under vacuum, the distillate sets slowly to a solid on standing. Stock reagents are made by dissolving the warm liquid in pentane, toluene, Et2O, THF, CH2Cl2,, and can be stored in a pure state or in solution under dry N2 for several months. The reagent is hygroscopic and is hydrolysed by H2O. [Reetz et al. Chem Ber 118 1421 1985.]
Precautions
Chlorotitanium triisopropoxide is corrosive; moisture sensitive; flammable liquid; can be stored under nitrogen, in pure form or in solution, for months.
