Description
Setiptiline is a mianserin analog reportedly useful in the treatment of depression with a
favorable side-effect profile. It is a potent antagonist of alpha-receptors, with greater
affinity at alpha, than alpha, sites, as well as an inhibitor of central serotonin receptors.
Chemical Properties
Flaky crystals. Soluble in ethyl acetate, benzene or chloroform, insoluble in ethanol. Melting point 138.5～139.5℃. Setiptiline Maleate: C19H19NC4H4O4.[57262-95-0]. White to slightly yellowish white crystalline powder, odorless, bitter taste. Soluble in chloroform, soluble in methanol, slightly soluble in ethanol, slightly soluble in water. Melting point 153～158℃.
Originator
Organon (Netherlands)
Uses
Setiptiline is a tetracyclic antidepressant. Setiptiline acts as a noradrenergic and specific serotonergic antidepressant (NaSSA).
Definition
ChEBI: Setiptiline is a tetracyclic antidepressant that is 2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine carrying a methyl group at position 2. Its maleate salt is used for the treatment of depression in Japan. It has a role as an alpha-adrenergic antagonist and a serotonergic antagonist. It is a tetracyclic antidepressant and a tertiary amino compound. It is a conjugate base of a setiptiline(1+).
