Description
Dehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC
50 value of 130 μM.
Chemical Properties
Pale Yellow Solid
Uses
Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.
Uses
The main Nifedipine metabolite in human plasma
Definition
ChEBI: Dehydronifedipine is a phenylpyridine.
Biochem/physiol Actions
CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.
