LOXO-292

LOXO-292 Price

LOXO-292 Chemical Properties,Usage,Production

Binding Mode

In the co-crystal structure of selpercatinib-RET kinase, the pyrazolopyridine occupies the adenosine pocket, forming a direct hydrogen bond between N1 and amide NH of Ala807 and an indirect hydrogen bond between C6 ether oxygen and amide NH of Gly810 via a bound water molecule. In addition, one piperazine nitrogen also interact with one water molecule (Figs. 3, 4).

Uses

Selpercatinib is a highly selective, potent RET inhibitor, an oral drug used to treat cancers in people whose tumours have been altered (mutated or fused) in specific genes (RET stands for "rearrangement during transfection").

brand name

Retevmo

General Description

Class: receptor tyrosine kinase; Treatment: RET-altered lung/thyroid cancers; Other name: ARRY-192, LOXO-292; Oral bioavailability = 73%; Elimination half-life = 32 h; Protein binding = 97%

Side effects

Selpercatinib can cause serious side effects including liver toxicity, high blood pressure, heart rhythm changes due to prolongation of heart electrical activity (QT prolongation), bleeding, allergic reactions, impaired wound healing and harm to an unborn baby.

Selpercatinib may cause harm to a developing fetus or a newborn baby.

target

RET

storage

Store at -20°C

Dosage

The recommended selpercatinib dose based on body weight is: (1) Less than 50 kg: 120 mg orally twice daily (2) 50 kg or greater: 160 mg orally twice daily

Preparation Products And Raw materials

LOXO-292 Supplier

Related articles

• LOXO-292: A Promising RET Inhibitor with Strong Anti-Tumor Effects and Manageable Adverse Events

  LOXO-292 inhibits RET-pathway, demonstrating anti-tumor effects and dose-proportional pharmacokinetics. Common adverse events occurred, with serious reactions in 33% of patients.

  Mar 4，2024

• Selpercatinib: Synthesis and Description

  Selpercatinib (LOXO-292) is synthesised using sulfonyl chloride as a raw material by chemical reaction.

  Jan 5，2024

LOXO-292: Bioactivity and Chemicaland toxicological studies

LOXO-292 is a selective and potent RET inhibitor,it is a novel broad-spectrum anticancer?drug with the targeted?function for RET protooncogene.There are three synthetic routes to selp

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View Lastest Price from LOXO-292 manufacturers

Selpercatinib; Loxo-292

$0.00-0.00/ MG

99% HPLC

HangZhou RunYan Pharma Technology Co.,LTD.

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Selpercatinib

$80.00-60.00/ kg

99%

hebei hongtan Biotechnology Co., Ltd

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LOXO-292

$50.00-30.00/ KG

99%

hebei hongtan Biotechnology Co., Ltd

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2152628-33-4, LOXO-292Related Search