Definition
ChEBI: 4-amino-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide is a member of benzenes and a sulfonamide.
Manufacturing Process
0.163 mol of 2-amino-5-ethyl-1,3,4-thiadiazole was covered with 43 parts of
anhydrous pyridine. To the mixture was added 50 parts (0.214 mol) of pacetylaminobenzenesulfonyl
chloride with vigorous shaking at 50°C to 60°C.
The reaction mixture was then heated to 125°C. When the mixture had cooled
somewhat it was placed in a Claisen flask and 27.6 parts (0.69 mol) of
sodium hydroxide dissolved in 110 parts of water was added through a
dropping funnel while distilling off a mixture of pyridine and water. The
distillation was stopped when the temperature reached 100°C and the residual
liquor in the flask heated at 95°C for 30 minutes.The reaction mixture was then poured into 1,650 parts of hot water, the pH
adjusted to 8 to 9, decolorizing charcoal was added and the whole was heated
on the steam for 15 minutes. The charcoal was filtered off and the hot filtrate
neutralized and cooled. The 2-(sulfanilamido)-5-ethyl-1,3,4-thiadiazole was
purified by repeated crystallization from boiling water.
![4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Structure](https://www.chemicalbook.com/CAS/GIF/94-19-9.gif)
